Orbitrap Exploris™ 120 (Thermo Scientific™) is a high-performance UHPLC-HRMS/MS system.

Features include: mass range 40–3000 Da, scan speed up to 22 Hz, resolution up to 120,000 FWHM at m/z 200, MS/MS sensitivity of 200 fg of reserpine on column, accuracy < 3 ppm, OptaMax™ NG source, full scan acquisition, tSIM, DIA, tMS2.

Data acquisition software: Thermo Scientific™ Xcalibur™.

This system is used for high-resolution accurate mass analysis, for the characterization of biomolecules (metabolomics, bottom-up and top-down proteomics, lipidomics) and for the identification and quantification of molecules in different biological matrices and plant extracts.

Available methods:

• High-resolution (HRMS) analysis of ionizable compounds in solution by direct infusion, providing exact mass for elemental formula confirmation;
• Qualitative/quantitative analysis of small molecules/biomarkers;
• Development of UHPLC-HRMS/MS methods for the identification and quantification of organic, biorganic, biopharmaceutical and organometallic compounds that are soluble and ionizable, in mixtures and complex matrices;
• Targeted and untargeted metabolomics studies;
• Structural characterization of peptides (Peptide Mapping);
• Drug screening;
• Intact protein analysis;
• Membrane lipid analysis;
• Pharmacokinetic studies.

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